Pathogen to commensal: longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection
T. Pearson, J. Sahl, C. M. Hepp, K. Handady, H. Hornstra, A. J. Vazquez, E. Settles, M. Mayo, M. Kaestli, C. H. D. Williamson, E. P. Price, D. S. Sarovich, J. M. Cook, S. R. Wolken, R. A. Bowen, , P. Keim
This study tracks the long-term evolution of Burkholderia pseudomallei in a human host over 16 years, showing its transition from a pathogen to a commensal through genetic and phenotypic changes.
bioRxiv · Feb 17, 2019Evolutionary Biology