Author

E. Settles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. Keim· 3 shared B. J. Currie· 2 shared A. H. Hirsch· 1 shared A. J. Vazquez· 1 shared A. Li· 1 shared A. T. Koppisch· 1 shared A. Tuanyok· 1 shared B. M. Barker· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

P. Keim

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

FXa cleaves the SARS-CoV-2 spike protein and blocks cell entry to protect against infection with inferior effects in B.1.1.7 variant

J. Yu, W. Dong, J. Wang, L. Tian, J. Zhang, H. L. Mead, S. Jaramillo, A. Li, R. Zumwalt, S. P. J. Whelan, E. Settles, P. Keim, B. M. Barker, M. Caligiuri

This study shows FXa cleaves SARS-CoV-2 spike protein, blocking viral entry, but B.1.1.7 variant is resistant, and FXa inhibitors like rivaroxaban reduce this protection.

bioRxiv · Jun 7, 2021 · PreprintMicrobiology

Soluble corn fiber reduces ovalbumin-induced sinonasal inflammation via the gut microbiota-airway axis

S. A. Jaramillo, E. M. Borsom, G. M. Orsini, O. Kask, K. Lee, A. H. Hirsch, E. Settles, X. Shi, H. Gu, A. T. Koppisch, N. Bokulich, J. G. Caporaso, E. K. Cope

This study shows soluble corn fiber reduces ovalbumin-induced sinonasal inflammation in mice, but this effect is lost in mice on a western diet due to microbiota changes.

bioRxiv · Jul 23, 2020 · PreprintMicrobiology

Pathogen to commensal: longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection

T. Pearson, J. Sahl, C. M. Hepp, K. Handady, H. Hornstra, A. J. Vazquez, E. Settles, M. Mayo, M. Kaestli, C. H. D. Williamson, E. P. Price, D. S. Sarovich, J. M. Cook, S. R. Wolken, R. A. Bowen, , P. Keim

This study tracks the long-term evolution of Burkholderia pseudomallei in a human host over 16 years, showing its transition from a pathogen to a commensal through genetic and phenotypic changes.

bioRxiv · Feb 17, 2019Evolutionary Biology

A Mouse Model Of Binge Alcohol Consumption and Burkholderia Infection

V. Jimenez, R. Moreno, E. Settles, B. J. Currie, P. Keim, F. Monroy

This study shows that binge alcohol consumption increases Burkholderia infection severity by reducing immune function and increasing tissue permeability and bacterial spread.

bioRxiv · Jul 30, 2018Immunology