Author

P. Keim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 6 Evolutionary Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:phylogenetics / evolution· 2 Assay:proteomics· 2

Frequent Co-Authors

B. M. Barker· 6 shared H. L. Mead· 4 shared B. J. Currie· 3 shared E. Settles· 3 shared A. Li· 2 shared A. Tuanyok· 2 shared D. R. Kollath· 2 shared G. R. Thompson· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

B. M. Barker

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Discovery and Repurposing of Pharmaceutical Agents as Antifungals: In vivo activity against Coccidioides

H. Mead, M. Valentine, G. R. Thompson, H. Yin, P. Keim, D. M. Engelthaler, B. M. Barker

The paper tests existing drugs for antifungal activity against Coccidioides in mice, finding that sertraline combined with fluconazole reduces lung fungal load.

bioRxiv · Feb 21, 2024 · PreprintMicrobiology

FXa cleaves the SARS-CoV-2 spike protein and blocks cell entry to protect against infection with inferior effects in B.1.1.7 variant

J. Yu, W. Dong, J. Wang, L. Tian, J. Zhang, H. L. Mead, S. Jaramillo, A. Li, R. Zumwalt, S. P. J. Whelan, E. Settles, P. Keim, B. M. Barker, M. Caligiuri

This study shows FXa cleaves SARS-CoV-2 spike protein, blocking viral entry, but B.1.1.7 variant is resistant, and FXa inhibitors like rivaroxaban reduce this protection.

bioRxiv · Jun 7, 2021 · PreprintMicrobiology

The K18-hACE2 Transgenic Mouse Model Recapitulates Non-Severe and Severe COVID-19 in Response to Infectious Dose of SARS-CoV-2 Virus

J. Yu, W. Dong, A. Li, J. Zhang, M. Caligiuri, S. Jaramillo, H. L. Mead, N. E. Stone, A. Jones, D. R. Kollath, V. K. Coyne, M. Yearsley, L.-S. Wang, B. M. Barker, P. Keim, T. Barr

The paper characterizes the K18-hACE2 mouse model's response to different SARS-CoV-2 doses, showing dose-dependent disease severity and recovery, and compares it to human COVID-19 pathology.

bioRxiv · May 8, 2021Microbiology

The Effect of Minnelide against SARS-CoV-2 in a Murine Model

M. C. Caballero Van Dyke, H. L. Mead, M. Bryant, K. L. Laux, D. R. Kollath, V. K. Coyne, K. J. Miller, N. E. Stone, S. A. Jaramillo, P. Keim, C. Milikowski, V. K. Gupta, S. M. Vickers, A. Saluja, M. R. Velagapudi, B. M. Barker

This study evaluates Minnelide's efficacy in treating SARS-CoV-2 infection in mice, showing reduced viral load, improved survival, and decreased inflammation.

bioRxiv · May 5, 2021 · PreprintMicrobiology

A two-hit epistasis model prevents core genome disharmony in recombining bacteria

A. J. Taylor, K. Yahara, B. Pascoe, L. Mageiros, E. Mourkas, J. K. Calland, S. Puranen, M. D. Hitchings, K. A. Jolley, C. M. Kobras, S. C. Bayliss, N. J. Williams, A. H. van Vliet, J. Parkhill, M. C. Maiden, , S. K. Sheppard

The paper shows that recombination in bacteria can overcome genomic disharmony through a two-hit epistasis model, allowing beneficial gene combinations to be reinstated in new genetic backgrounds.

bioRxiv · Mar 15, 2021 · PreprintMicrobiology

Differential thermotolerance adaptation between species of Coccidioides

H. L. Mead, P. S. Hamm, I. N. Shaffer, M. de Melo Teixeira, C. Wendel, N. P. Wiederhold, G. R. Thompson, R. Muniz-Salazar, L. R. Castanon-Olivares, P. Keim, C. Plude, J. Terriquez, J. N. Galgiani, M. J. Orbach, B. M. Barker

This study compares thermotolerance between two Coccidioides species by measuring growth rates at different temperatures, finding C. posadasii grows faster at 37°C than C. immitis.

bioRxiv · Aug 12, 2020Microbiology

Strong population structure in Venezuelan populations of Coccidioides posadasii

M. M. Teixeira, P. Alvarado, C. Roe, G. Thompson, J. S. L. Patane, J. W. Sahl, P. Keim, J. N. Galgiani, A. P. Litvintseva, D. R. Matute, B. M. Barker

The paper identifies strong population structure and genetic differentiation in Coccidioides posadasii from Venezuela compared to North American populations, with evidence of admixture in Central America.

bioRxiv · Jul 30, 2019 · PreprintEvolutionary Biology

Pathogen to commensal: longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection

T. Pearson, J. Sahl, C. M. Hepp, K. Handady, H. Hornstra, A. J. Vazquez, E. Settles, M. Mayo, M. Kaestli, C. H. D. Williamson, E. P. Price, D. S. Sarovich, J. M. Cook, S. R. Wolken, R. A. Bowen, , P. Keim

This study tracks the long-term evolution of Burkholderia pseudomallei in a human host over 16 years, showing its transition from a pathogen to a commensal through genetic and phenotypic changes.

bioRxiv · Feb 17, 2019Evolutionary Biology

Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure

J. Yi, M. F. Simpanya, E. W. Settles, A. B. Shannon, K. Hernandez, L. Pristo, M. Keener, H. Hornstra, J. D. Busch, C. Soffler, P. J. Brett, B. J. Currie, R. A. Bowen, A. Tuanyok, P. Keim

This study characterizes the caprine humoral immune response to Burkholderia pseudomallei during aerosol-induced melioidosis, identifying immunogenic proteins that may serve as diagnostic biomarkers.

bioRxiv · Sep 17, 2018Immunology

A Mouse Model Of Binge Alcohol Consumption and Burkholderia Infection

V. Jimenez, R. Moreno, E. Settles, B. J. Currie, P. Keim, F. Monroy

This study shows that binge alcohol consumption increases Burkholderia infection severity by reducing immune function and increasing tissue permeability and bacterial spread.

bioRxiv · Jul 30, 2018Immunology