Author

T. Pearson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 2 Animal Behavior & Cognition· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:phylogenetics / evolution· 2 Approach:statistical model· 2

Frequent Co-Authors

B. J. Currie· 2 shared J. Sahl· 2 shared M. Mayo· 2 shared P. Keim· 2 shared A. Burgos-Mayorga· 1 shared A. E. Munsterberg· 1 shared A. J. Vazquez· 1 shared A. Kipar· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersEvolutionary Biology

B. J. Currie

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Population sequencing for diversity and transmission analyses

T. Pearson, T. Furstenau, C. Wood, V. Rigas, J. Sahl, S. Maltinsky, B. J. Currie, M. Mayo, C. Hall, P. Keim, V. Fofanov

This paper introduces and validates population sequencing methods to analyze phylogenetic diversity in bacterial populations without haplotype reconstruction, demonstrating applications in tracking transmission and understanding pathogen dynamics.

bioRxiv · Jun 18, 2024 · PreprintEvolutionary Biology

Domestic dogs in indigenous Amazonian communities: key players in Leptospira cycling and transmission?

D. A. Guzman, E. Diaz, C. Saenz, H. Alvarez, R. Cueva, G. Zapata-Rios, B. Prado-Vivar, M. Falconi, T. Pearson, V. Barragan

This study finds high prevalence of Leptospira antibodies and DNA in domestic dogs from Amazonian communities, suggesting their role in Leptospira cycling and transmission.

bioRxiv · Sep 19, 2023 · PreprintMicrobiology

Muscle stem cell function is impaired in absence of Talpid3 - a gene required for primary cilia formation

V. Martinez-Heredia, D. Blackwell, S. Sebastian, T. Pearson, G. F. Mok, L. Mincarelli, C. Utting, L. Folkes, E. Poschl, I. C. Macaulay, U. C. Mayer, A. E. Munsterberg

This study shows that Talpid3 is essential for muscle stem cell self-renewal and regeneration, and pharmacological Wnt activation can restore regeneration in its absence.

bioRxiv · Oct 14, 2022Cell Biology

First detection of Leptospira santarosai in the reproductive track of a boar: a potential threat to swine production and public health

E. A. Diaz, L. Luna, A. Burgos-Mayorga, G. Donoso, D. Guzman, M. I. Baquero, T. Pearson, V. A. Barragan

The paper reports the first detection of Leptospira santarosai in a vaccinated boar's reproductive tract, highlighting the need for better vaccine strategies against local variants.

bioRxiv · Apr 20, 2022Microbiology

The Effects of Strain and Estrous Cycle on Heroin- and Sucrose-Maintained Responding in Female Rats

K. T. Schmidt, J. L. Sharp, S. B. Ethridge, T. Pearson, S. Ballard, K. M. Potter, M. A. Smith

This study shows that heroin intake, but not sucrose intake, decreases during proestrus in female rats across three strains.

bioRxiv · Nov 6, 2020Animal Behavior & Cognition

The WD and linker domains of ATG16L1 required for non canonical autophagy limit lethal influenza A virus infection at epithelial surfaces.

Y. Wang, W. Zhang, M. Jefferson, P. Sharma, B. Bone, A. Kipar, J. L. Coombes, T. Pearson, A. Mann, A. Zhekova, Y. Bao, R. A. Tripp, Y. Yamauchi, S. R. Carding, U. Mayer, , T. Wileman

This study shows that non-canonical autophagy, mediated by the WD and linker domains of ATG16L1, protects against lethal influenza A virus infection by limiting viral replication and inflammation in airway epithelial cells.

bioRxiv · Jan 15, 2020 · PreprintMicrobiology

Pathogen to commensal: longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection

T. Pearson, J. Sahl, C. M. Hepp, K. Handady, H. Hornstra, A. J. Vazquez, E. Settles, M. Mayo, M. Kaestli, C. H. D. Williamson, E. P. Price, D. S. Sarovich, J. M. Cook, S. R. Wolken, R. A. Bowen, , P. Keim

This study tracks the long-term evolution of Burkholderia pseudomallei in a human host over 16 years, showing its transition from a pathogen to a commensal through genetic and phenotypic changes.

bioRxiv · Feb 17, 2019Evolutionary Biology