Y. W. Lim

This study shows that anti-CTLA-4 antibodies with reduced checkpoint inhibition have better anti-tumor efficacy and lower toxicity by primarily depleting tumor-infiltrating Tregs via FcR signaling.

The paper shows that the balance between PAR-2 and PAR-6 proteins determines whether C. elegans embryos undergo asymmetric or symmetric cell division.

This paper demonstrates a technology to capture and recreate diverse antibody repertoires as multivalent recombinant drugs, showing applications against SARS-CoV-2, Zika virus, and graft-versus-host disease.

The paper engineers the auroramycin biosynthetic pathway in Streptomyces roseoporous to identify key structural features responsible for its antimicrobial activity.

The paper generates 3D maps of microbiomes and metabolomes in cystic fibrosis lungs, revealing personalized and regiospecific chemical environments and microbial interactions.