Author

J. Scheen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:protein structure· 1 Organism:virus· 1

Frequent Co-Authors

A. V. Chandran· 2 shared B. H. Balcomb· 2 shared C. W. E. Tomlinson· 2 shared D. FearoniD· 2 shared F. von DelftiD· 2 shared J. C. Aschenbrenner· 2 shared L. KoekemoeriD· 2 shared M. FairheadiD· 2 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. V. Chandran

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2 papers

Recent·Most cited

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors

X. Ni, R. B. Richardson, A. S. de Godoy, M. P. Ferla, C. Kikawa, J. Scheen, W. W. Hannon, E. Capkin, N. Lahav, B. H. Balcomb, P. G. Marples, M. Fairhead, S. Wang, E. Williams, C. W. E. Tomlinson, , F. von Delft

The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.

bioRxiv · Apr 29, 2024 · PreprintBiochemistry

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase

A. S. Godoy, N. C. M. R. Mesquita, C. Giroud, G. D. Noske, V. O. Gawriljuk, R. M. Lithgo, B. H. Balcomb, J. C. Aschenbrenner, C. W. E. Tomlinson, M. Winokan, J. Scheen, H. MacDermott-Opeskin, P. G. Marples, A. V. Chandran, X. Ni, , F. von Delft

This study uses high-throughput crystallographic fragment screening to identify 46 fragment binding poses on ZIKV NS3Hel, providing templates for antiviral drug design.

bioRxiv · Apr 27, 2024 · PreprintBiophysics