CoCl2 triggered pseudohypoxic stress induces proteasomal degradation of SIRT4 via polyubiquitination of lysines K78 and K299
N. Hampel, J. Georgy, M. Mehrabipour, A. Lang, J. Scheller, M. R. Ahmadian, D. M. Floss, R. P. Piekorz
This study shows CoCl2 induces SIRT4 degradation through proteasomal polyubiquitination at K78 and K299, and via autophagy/mitophagy.
bioRxiv · May 16, 2023 · PreprintBiochemistry