A. Lang

Novel fluorescence-based methods to determine infarct and scar size in murine models of reperfused myocardial infarction

The paper compares fluorescence staining methods to classical histochemical techniques for determining infarct and scar size in murine reperfused myocardial infarction models.

Cyr61 delivery promotes angiogenesis during bone fracture repair

This study shows that Cyr61 delivery enhances angiogenesis during bone fracture repair, particularly in fractures with stable fixation, and may have therapeutic potential for poor vascularization.

Identification of SIRT4 as a novel paralog-specific interactor and candidate suppressor of C-RAF kinase in MAPK signaling

This study identifies SIRT4 as a specific interactor of C-RAF kinase, showing it suppresses MAPK signaling by stabilizing the inactive form of C-RAF.

RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

This study identifies RBM39 as a regulator of innate immunity by controlling transcription and splicing of key interferon response factors, revealing its potential as a therapeutic target.

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

This study shows that inhibiting CDK12 and CDK13 reduces glioma cell proliferation and migration, and disrupts transcription and cell cycle progression in glioblastoma.

Modulation of functional phosphorylation sites by basic residues in the Unique domain of c-Src

The paper investigates how basic residues modulate phosphorylation sites in the SNRE of c-Src using NMR and mutations, revealing electrostatic interactions and their effects on conformation.

CoCl2 triggered pseudohypoxic stress induces proteasomal degradation of SIRT4 via polyubiquitination of lysines K78 and K299

This study shows CoCl2 induces SIRT4 degradation through proteasomal polyubiquitination at K78 and K299, and via autophagy/mitophagy.

Inhibition of CD40-TRAF6 signaling protects against aneurysm development and progression

This study shows that inhibiting CD40-TRAF6 signaling reduces abdominal aortic aneurysm severity and progression in mice.

Using TCR and BCR sequencing to unravel the role of T and B cells in abdominal aortic aneurysm

This study uses scRNA TCR and BCR sequencing to analyze T and B cell responses in murine AAA, finding no clonal expansion of TCRs or BCRs.

A Buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72h in mouse femoral fracture models

This study evaluates a new Buprenorphine depot formulation (BUP-Depot) for sustained post-surgical analgesia in mouse femoral fracture models, finding it effective for 72h and comparable to Tramadol in drinking water.

Loss-of-function mutation in human Oxidation Resistance gene 1 disrupts the spatial-temporal regulation of histone arginine methylation in early brain development

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, beta, delta, and omicron variants

The paper assesses neutralizing antibody responses of convalescent and vaccinated sera against SARS-CoV-2 ancestral, beta, delta, and omicron variants.

Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence

The paper shows that quiescent human keratinocyte monolayers undergo stress amplification and fluidization upon serum stimulation, linking mechanical stress to tissue motility.

Prolactin and prolactin receptor expression in the HPG axis and crop sac during parental care in both sexes of a biparental bird (Columba livia)

This study examines prolactin and prolactin receptor expression in the HPG axis and crop sac during parental care in both sexes of rock doves, finding sex differences and tissue-specific responses to offspring presence.

Proteasome autophagy is specifically regulated and requires factors dispensible for general autophagy

The paper investigates proteasome autophagy regulation, showing it is distinct from general autophagy and requires specific factors like Atg11 and map kinases.

Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted heart

The paper uses single-cell RNA sequencing to identify distinct epicardial stromal cell populations in infarcted mouse hearts and their potential cardiomyogenic properties.

Isolating the role of corticosterone in the hypothalamic-pituitary-gonadal genomic stress response

This study examines the genomic effects of corticosterone on the HPG axis in rock doves under stress, identifying sex-specific gene expression changes and shared genes in the pituitary.

Acidic monosaccharides become incorporated into calcite single crystals

This study shows acidic monosaccharides incorporate into calcite crystals, altering their structure and inducing anisotropic lattice distortions.

Bio-Inspired Molecular Bridging in a Hybrid Perovskite Leads to Enhanced Stability and Tunable Properties

This paper introduces a bio-inspired method to enhance hybrid perovskite stability and tune its properties by incorporating amino acids into its lattice.

HIF-stabilization prevents delayed fracture healing

This study shows that stabilizing HIF-1α with deferoxamine and macrophage migration inhibitory factor improves fracture healing in a mouse model by enhancing calcification, osteogenic differentiation, and vascularization.

An in vitro human-based fracture gap model - Mimicking the crosstalk between bone and immune cells

This study develops an in vitro 3D fracture gap model that mimics bone-immune cell interactions to study fracture healing mechanisms and therapeutic responses.

Subcellular localization and mitotic interactome analyses identify SIRT4 as a centrosomally localized and microtubule associated protein

This study identifies SIRT4 as a centrosomal and microtubule-associated protein that delays mitotic progression and reduces cell proliferation.

In vitro and in silico modeling of cellular and matrix-related changes during the early phase of osteoarthritis

This study combines in vitro and in silico models to simulate early osteoarthritis changes, showing inflammation-induced matrix degradation and partial reversibility.

Strong positive biodiversity-productivity relationships in a subtropical forest experiment

The paper demonstrates a strong positive biodiversity-productivity relationship in a subtropical forest experiment, showing increased productivity with species richness and complementary effects over time.