Author

J. Schinkel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

K. Sliepen· 3 shared A. B. Ward· 2 shared A. Chumbe· 2 shared J. Capella-Pujol· 2 shared R. W. Sanders· 2 shared A. I. Schriek· 1 shared A. J. R. Heck· 1 shared A. Torrents de la Pena· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersImmunology

K. Sliepen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

L. Radic, K. Sliepen, V. Yin, M. Brinkkemper, J. Capella-Pujol, A. I. Schriek, J. L. Torres, S. Bangaru, J. A. Burger, M. Poniman, I. Bontjer, J. H. Bouhuijs, D. Gideonse, D. Eggink, A. B. Ward, , J. Schinkel

This study shows bispecific antibodies combine the neutralizing breadth and potency of parental antibodies to neutralize SARS-CoV and SARS-CoV-2 variants, including Omicron.

bioRxiv · Nov 11, 2022Immunology

Structure of the hepatitis C virus E1E2 glycoprotein complex

A. Torrents de la Pena, K. Sliepen, L. Eshun-Wilson, M. Newby, J. D. Allen, S. Koekkoek, I. Zon, A. Chumbe, M. Crispin, J. Schinkel, G. C. Lander, R. W. Sanders, A. B. Ward

The paper presents the cryo-EM structure of the HCV E1E2 glycoprotein complex with antibodies, revealing the E1-E2 interface and its stabilization mechanisms.

bioRxiv · Dec 16, 2021 · PreprintImmunology

Optimised cell systems for the investigation ofhepatitis C virus E1E2 glycoproteins

M. D. Kalemera, J. Capella-Pujol, A. Chumbe, A. Underwood, R. A. Bull, J. Schinkel, K. Sliepen, J. Grove

This paper identifies an optimized cell line for producing HCV pseudoparticles and reveals antigenic differences between sE2 produced in 293T and 293F cells.

bioRxiv · Jun 18, 2020 · PreprintMicrobiology

High resolution evolutionary analysis of within-host hepatitis C virus infection

J. Raghwani, C.-H. Wu, C. K. Ho, M. de Jong, R. Molenkamp, J. Schinkel, O. G. Pybus, K. A. Lythgoe

This study analyzes within-host HCV evolution in HIV-coinfected individuals, finding population structure, regional variation in mutation rates, and a low recombination rate.

bioRxiv · Aug 28, 2018Evolutionary Biology