Author

D. Eggink

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 6 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

R. W. Sanders· 4 shared A. B. Ward· 3 shared J. A. Burger· 3 shared K. Sliepen· 3 shared M. Poniman· 3 shared A. J. R. Heck· 2 shared A. J. W. te Velthuis· 2 shared C. A. Russell· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersImmunology

R. W. Sanders

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Asymmetrical Bi-antennary Glycans Prepared by a Stop-and-Go Strategy Reveal Receptor Binding Evolution of Human Influenza A Viruses

S. Ma, L. Liu, D. Eggink, S. Herfst, R. A. M. Fouchier, R. P. de Vries, G.-J. Boons

This paper develops a stop-and-go chemoenzymatic method to synthesize asymmetrical bi-antennary glycans and uses them to study receptor binding evolution of human influenza A viruses.

bioRxiv · Nov 8, 2023Biochemistry

Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines

I. del Moral-Sanchez, E. G. Wee, Y. Xian, W.-H. Lee, J. D. Allen, A. Torrents de la Pena, R. d. P. F. Rocha, J. Ferguson, A. N. Leon, S. Koekkoek, E. E. Schermer, J. A. Burger, S. Kumar, R. Zwolsman, M. Brinkkemper, , R. W. Sanders

The paper introduces a triple tandem trimer (TTT) design for HIV-1 Env and influenza HA immunogens, showing improved trimer-specific immune responses in viral vectored vaccines.

bioRxiv · Aug 27, 2023Microbiology

Evolution of transient RNA structure-RNA polymerase interactions in respiratory RNA virus genomes

C. V. Rigby, K. R. Sabsay, K. Bisht, D. Eggink, H. Jalal, A. J. W. te Velthuis

The paper examines how RNA structures in influenza A viruses change during adaptation to humans, finding reduced free energy in template loops associated with increased replication efficiency.

bioRxiv · May 25, 2023 · PreprintMicrobiology

Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

L. Radic, K. Sliepen, V. Yin, M. Brinkkemper, J. Capella-Pujol, A. I. Schriek, J. L. Torres, S. Bangaru, J. A. Burger, M. Poniman, I. Bontjer, J. H. Bouhuijs, D. Gideonse, D. Eggink, A. B. Ward, , J. Schinkel

This study shows bispecific antibodies combine the neutralizing breadth and potency of parental antibodies to neutralize SARS-CoV and SARS-CoV-2 variants, including Omicron.

bioRxiv · Nov 11, 2022Immunology

Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual

D. Guerra, T. Beaumont, L. Radic, G. Kerster, K. van der Straten, M. Yuan, J. L. Torres, W.-H. Lee, H. Liu, M. Poniman, I. Bontjer, J. A. Burger, M. Claireaux, T. G. Caniels, J. L. Snitselaar, , M. J. van Gils

This study identifies broadly neutralizing monoclonal and bispecific antibodies from a Gamma variant-infected individual that effectively neutralize multiple SARS-CoV-2 variants.

bioRxiv · Oct 14, 2022Immunology

IgG1 responses following SARS-CoV-2 infection are polyclonal and highly personalized, whereby each donor and each clone displays a distinct pattern of cross-reactivity against SARS-CoV-2 variants

D. M. H. van Rijswijck, A. Bondt, M. Hoek, K. van der Straten, T. G. Caniels, M. Poniman, D. Eggink, C. B. E. M. Reusken, G. J. de Bree, R. W. Sanders, M. van Gils, A. J. R. Heck

The paper analyzes IgG1 clonal responses to SARS-CoV-2 variants in infected donors, finding unique and polyclonal antibody repertoires with varying cross-reactivity across variants.

bioRxiv · Feb 24, 2022Immunology

A SARS-CoV-2 mini-genome assay based on negative-sense RNA to study replication inhibitors and emerging mutations

T. Vial, M. S. Oade, C. A. Russell, D. Eggink, A. J. W. te Velthuis

This paper develops a mini-genome assay using negative-sense RNA to study SARS-CoV-2 replication inhibitors and mutations, offering high sensitivity and ease of use in standard labs.

bioRxiv · Jun 28, 2021 · PreprintMicrobiology

Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children

A. X. Han, Z. C. Felix Garza, M. R. A. Welkers, R. M. Vigeveno, N. D. Tran, T. Q. M. Le, Q. T. Pham, D. T. Dang, T. N. A. Tran, M. T. Ha, T. H. Nguyen, Q. T. Le, T. H. Le, T. B. N. Hoang, K. Chokephaibulkit, , C. A. Russell

This study examines within-host evolutionary dynamics of seasonal and pandemic influenza A viruses in young children, finding that nonsynonymous mutations decrease over time in A/H1N1pdm09 but increase in A/H3N2 due to mutation-selection balance.

bioRxiv · Mar 20, 2021Microbiology