Author

J. Schwerk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

R. Savan· 3 shared A. Forero· 2 shared J. J. Woodward· 2 shared J. L. Hyde· 2 shared J. R. Smith· 2 shared S. A. Zaver· 2 shared A. E. L. Stone· 1 shared A. Karp· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

R. Savan

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Author profile →

3 papers

Recent·Most cited

MEF2A suppresses replicative stress responses that trigger DDX41-dependent IFN production

J. R. Smith, J. W. Dowling, A. Karp, J. Schwerk, R. Savan, A. Forero

This study shows MEF2A suppresses type I IFN production by preventing R-loop accumulation and DDX41/STING pathway activation in response to replicative stress.

bioRxiv · Sep 15, 2022Immunology

Sequence diversity in the 3' untranslated region of alphavirus modulates IFIT2-dependent restriction in a cell type-dependent manner

S. E. Hickson, E. Brekke, J. Schwerk, I. Salukhe, S. A. Zaver, J. J. Woodward, R. Savan, J. L. Hyde

This study shows that variability in the 3UTR of VEEV modulates IFIT2-dependent restriction, with differential sensitivity observed in vitro.

bioRxiv · Dec 10, 2021Microbiology

Endomembrane targeting of human OAS1 p46 augments antiviral activity

F. W. Soveg, J. Schwerk, N. S. Gokhale, K. Cerosaletti, J. R. Smith, E. Pairo-Castineira, A. M. Kell, A. Forero, S. A. Zaver, K. Esser-Nobis, J. Roby, T.-Y. Hsiang, S. Ozarkar, J. M. Clingan, E. T. McAnarney, , R. Savan

This study shows that the OAS1 p46 isoform, targeted to the endomembrane system, enhances antiviral activity against RNA viruses and is associated with COVID-19 severity.

bioRxiv · Apr 21, 2021Immunology