R. Savan

Cellular RNA interacts with MAVS to promote antiviral signaling

The paper shows that cellular RNA interacts with MAVS to scaffold signaling proteins and promote antiviral signaling by facilitating IRF3 phosphorylation.

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

This study identifies CARD8 as a sensor for viral proteases, showing it activates inflammasomes in response to coronavirus 3CLpro and can be modulated by genetic variation.

MEF2A suppresses replicative stress responses that trigger DDX41-dependent IFN production

This study shows MEF2A suppresses type I IFN production by preventing R-loop accumulation and DDX41/STING pathway activation in response to replicative stress.

Cardiopulmonary bypass activates classical monocytes via shear-mediated activation of Store-Operated Calcium Entry

The paper identifies SPTAN1 and RAF1 as genes activated by shear stress during cardiopulmonary bypass, leading to inflammation and cell death through store-operated calcium entry.

Sequence diversity in the 3' untranslated region of alphavirus modulates IFIT2-dependent restriction in a cell type-dependent manner

This study shows that variability in the 3UTR of VEEV modulates IFIT2-dependent restriction, with differential sensitivity observed in vitro.

Active Translation Control of CD4 T Cell Activation by Regulatory T Cells

This study shows regulatory T cells suppress CD4 T cell activation by inhibiting translation of mRNAs encoding protein synthesis machinery, highlighting translational control in immune tolerance.

Endomembrane targeting of human OAS1 p46 augments antiviral activity

This study shows that the OAS1 p46 isoform, targeted to the endomembrane system, enhances antiviral activity against RNA viruses and is associated with COVID-19 severity.