Author

J. Selich-Anderson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Taslim· 3 shared E. R. Theisen· 3 shared S. L. Lessnick· 3 shared I. A. Showpnil· 2 shared J. C. Crow· 2 shared M. A. Boone· 2 shared B. D. Sunkel· 1 shared B. Z. Stanton· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

C. Taslim

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4 papers

Recent·Most cited

Cancer BiologybioRxivSep 30, 2021

EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma

I. A. Showpnil, J. Selich-Anderson, C. Taslim…·S. L. Lessnick

This study identifies how EWS/FLI fusion proteins alter chromatin structure and transcription in Ewing sarcoma, highlighting their role in reprogramming 3D chromatin to drive transcriptional changes.

DOI 10.1093/nar/gkac747

humanChIP-seq

𝕏 PostBluesky

Cancer BiologyEpigeneticsPeer-reviewedApr 3, 2021

Chromatin profiling reveals reorganization of lysine specific demethylase 1 by an oncogenic fusion protein

E. R. Theisen, J. Selich-Anderson, K. R. Miller…·S. L. Lessnick

The paper shows EWS/FLI fusion protein alters LSD1 distribution and function, impacting enhancer landscapes and gene activation in Ewing sarcoma.

DOI 10.1080/15592294.2020.1805678

humanChIP-seq

𝕏 PostBluesky

Cancer BiologybioRxivOct 29, 2020

The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma

M. A. Boone, C. Taslim, J. C. Crow…·S. L. Lessnick

This study identifies the specific FLI regions in EWS/FLI critical for oncogenic transformation in Ewing sarcoma, showing the DNA-binding domain and a carboxyl-terminal alpha-helix are essential for transcriptional regulation and tumorigenesis.

DOI 10.1038/s41388-021-01876-5

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivMar 5, 2018

Dual BRD4 and AURKA Inhibition is Synergistic against MYCN-amplified and nonamplified Neuroblastoma

J. Felgenhauer, L. Tomino, J. Selich-Anderson…·N. Shah

This paper shows that combining BRD4 and AURKA inhibitors synergistically inhibits neuroblastoma cell viability and prolongs survival in xenograft models.

DOI 10.1016/j.neo.2018.08.002

humanexperimental assay

𝕏 PostBluesky