J. Slager

High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation

This study analyzes the gut microbiome of treated coeliac disease patients at strain level, revealing increased interindividual variation and specific microbial associations.

Refining the pneumococcal competence regulon by RNA-sequencing

The paper uses RNA-seq to refine the pneumococcal competence regulon, identifying 4% of genes directly controlled by ComE/ComX and up to 17% affected overall.

Antibiotic-induced cell chaining triggers pneumococcal competence by reshaping quorum sensing to autocrine-like signaling

This study shows that antibiotics like aztreonam and clavulanic acid induce pneumococcal competence by promoting cell chaining, which alters quorum sensing to autocrine-like signaling.

High-resolution analysis of the pneumococcal transcriptome under a wide range of infection-relevant conditions

This study profiles the pneumococcal transcriptome under 22 infection-relevant conditions, revealing dynamic gene expression and identifying a new competence regulon member.

RocS drives chromosome segregation and nucleoid occlusion in Streptococcus pneumoniae

This study identifies RocS as essential for chromosome segregation and nucleoid occlusion in Streptococcus pneumoniae, linking it to capsule biogenesis and cell division.

Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39

This study annotates the genome of Streptococcus pneumoniae D39 using long-read sequencing and transcriptomics, identifying new genes, sRNAs, and operon structures.

High-throughput CRISPRi phenotyping in Streptococcus pneumoniae identifies new essential genes involved in cell wall synthesis and competence development

This study uses CRISPRi to identify essential genes in S. pneumoniae, revealing roles in cell wall synthesis and competence development, and highlights potential antibiotic targets.