High CXCL6 drives matrix expression and correlate with markers of poor outcome in IPF
H. Bahudhanapati, J. Tan, R.-M. Apel, B. Seeliger, X. Li, T.-Y. Chen, D. Sullivan, J. Sembrat, M. Rojas, E. Valenzi, R. A. Lafyatis, C. Jawale, P. Biswas, J. Tedrow, T. S. Adams, , D. J. Kass
This study identifies CXCL6 as a pro-fibrotic factor in IPF, showing it reduces cAMP, increases collagen and -SMA, and correlates with poor patient survival.
bioRxiv · Jun 22, 2021 · PreprintCell Biology