M. Rojas

Single Cell MALDI-MSI Analysis of Lipids and Proteins within a Replicative Senescence Fibroblast Model

This study uses MALDI-MSI to analyze lipids and proteins in human lung fibroblasts, revealing senescence-related changes at the single-cell level.

Translational activation by a synthetic PPR protein elucidates control of psbA translation in Arabidopsis chloroplasts

A synthetic PPR protein substitutes for HCF173, elucidating its role in activating psbA translation and demonstrating synthetic PPRs' ability to control chloroplast gene expression.

A redox-shifted fibroblast subpopulation emerges in the fibrotic lung.

The paper identifies a redox-shifted fibroblast subpopulation in fibrotic lungs, showing increased pro-fibrotic activity and reduced collagenolytic activity.

Optimal transport for mapping senescent cells in spatial transcriptomics

The paper develops scDOT, a method combining spatial transcriptomics and single-cell RNA-seq with optimal transport to improve spatial mapping of senescent cells and identify novel genes involved in cell-cell interactions.

RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension

This study shows RAB7 deficiency impairs endothelial function and causes pulmonary hypertension in mice, with potential for RAB7 activation as a therapeutic strategy.

GPER-dependent estrogen signaling increases cardiac GCN5L1 expression and MCAD activity

This study shows that estrogen signaling through GPER increases GCN5L1 expression and MCAD activity in cardiac cells, affecting mitochondrial enzyme acetylation and metabolic fuel utilization.

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

This study shows that BRAF activation induces cardiac hypertrophy in mice, and Type 1 RAF inhibitors paradoxically promote hypertrophy by increasing ERK1/2 phosphorylation.

High CXCL6 drives matrix expression and correlate with markers of poor outcome in IPF

This study identifies CXCL6 as a pro-fibrotic factor in IPF, showing it reduces cAMP, increases collagen and -SMA, and correlates with poor patient survival.

Seronegative MSM at high-risk of HIV-1 acquisition show Immune quiescent profile with normal immune response against common antigens

This study compares the immunological profiles of high-risk and low-risk HIV-negative MSM, finding a quiescent immune profile and increased Serpin A1 expression in high-risk individuals.

ER exit sites in Drosophila display abundant ER-Golgi vesicles and pearled tubes but no megacarriers

The paper examines ER exit sites in Drosophila, finding pre-cis-Golgi regions and pearled tubes but no megacarriers for ER-Golgi transport.

PECAM-1 preserves cardiac function in pressure overload-induced biomechanical stress

This study shows that PECAM-1 helps maintain cardiac function under pressure overload by regulating remodelling and JNK signalling.

In vivo stabilization of endogenous chloroplast RNAs by customized artificial pentatricopeptide repeat proteins

This study demonstrates that artificial PPR proteins can stabilize specific chloroplast RNAs in vivo by mimicking natural PPR proteins' functions.

Analysis of SARS-CoV-2 ORF3a structure reveals chloride binding sites

The paper analyzes the structure of SARS-CoV-2 ORF3a, identifying chloride binding sites and their dynamic behavior in a simulated tetramer.

AKT-like kinase promotes cell survival during nutritional stress in trypanosomatids

This paper shows that inhibiting AKT-like kinase in trypanosomatids reduces their survival during nutritional stress and infectivity.

Using High Throughput DNA Sequencing to Evaluate the Accuracy of Serial Dilution Based Tests of Microbial Activities in Oil Pipelines

This study uses high-throughput DNA sequencing to assess microbial composition changes in serial dilution tests, revealing inaccuracies in detecting specific bacterial functions and abundances.