Author

J. Sembrat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Nouraie· 2 shared A. Alsuraimi· 1 shared A. B. Waxman· 1 shared A. C. Straub· 1 shared A. Crane· 1 shared A. Dosunmu-Ogunbi· 1 shared A. Gorelova· 1 shared A. Gurkar· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

M. Nouraie

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Author profile →

4 papers

Recent·Most cited

GCN5L1-mediated acetylation prevents Rictor degradation in cardiac cells after hypoxic stress

P. Bugga, J. R. Manning, B. A. Mushala, M. W. Stoner, J. Sembrat, I. Scott

This study shows GCN5L1 prevents Rictor degradation in cardiac cells under hypoxia by acetylating Rictor, thereby maintaining Akt/mTORC2 signaling and protecting against ischemic injury.

bioRxiv · Oct 26, 2023Cell Biology

Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Reprogramming of Aortic Valve Cells Through STAT5

R. A. Cuevas, L. Hortells, C. Chu, R. Wong, A. Crane, C. Boufford, C. Regan, W. Moorhead, M. Bashline, A. Parwal, A. Parise, P. Behzadi, A. Gurkar, D. Bruemmer, J. Sembrat, , C. St. Hilaire

This study identifies TERT's non-canonical role in osteogenic reprogramming of aortic valve cells through STAT5, offering a potential therapeutic target for calcific aortic valve disease.

bioRxiv · Aug 23, 2022Pathology

The Role of EBP50 in Regulating Endothelial-To-Mesenchymal Transition in Pulmonary Hypertension

A. Gorelova, M. Berman, M. Sharifi-Sanjani, A. Pulgarin Rocha, A. Alsuraimi, P. Riva, V. Negi, T. Bertero, D. Goncharov, T. Kudryashova, A. Dosunmu-Ogunbi, A. Rajaratnam, L. Harvey, M. Nouraie, J. Baust, , I. Al Ghouleh

This study shows EBP50 downregulation promotes EndMT in pulmonary hypertension by increasing Snail, Zeb1, and Slug expression, and mesenchymal markers, while reducing cell proliferation and barrier function.

bioRxiv · May 31, 2022 · PreprintCell Biology

High CXCL6 drives matrix expression and correlate with markers of poor outcome in IPF

H. Bahudhanapati, J. Tan, R.-M. Apel, B. Seeliger, X. Li, T.-Y. Chen, D. Sullivan, J. Sembrat, M. Rojas, E. Valenzi, R. A. Lafyatis, C. Jawale, P. Biswas, J. Tedrow, T. S. Adams, , D. J. Kass

This study identifies CXCL6 as a pro-fibrotic factor in IPF, showing it reduces cAMP, increases collagen and -SMA, and correlates with poor patient survival.

bioRxiv · Jun 22, 2021 · PreprintCell Biology