Author

J. V. Rodrigues

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

E. Shakhnovich· 2 shared D. L. Hartl· 1 shared E. I. Shakhnovich· 1 shared E. R. Lozovsky· 1 shared S. Chowdhury· 1 shared V. Y. Zhao· 1 shared Y. Zhang· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

E. Shakhnovich

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3 papers

Recent·Most cited

BiophysicsbioRxivJun 18, 2021

Switching an active site helix in dihydrofolate reductase reveals limits to sub-domain modularity

V. Y. Zhao, J. V. Rodrigues, E. R. Lozovsky…·E. I. Shakhnovich

This study replaces a helical segment in DHFR with sequences from unrelated proteins, showing that while chimeras fold, their activity and stability are reduced, highlighting limits to sub-domain modularity.

DOI 10.1016/j.bpj.2021.09.032

E. coliprotein structure

𝕏 PostBluesky

BiophysicsbioRxivOct 30, 2020

Development of antibacterial compounds that block evolutionary pathways to resistance

Y. Zhang, S. Chowdhury, J. V. Rodrigues, E. Shakhnovich

This study identifies a compound that inhibits both wild-type and TMP-resistant variants of E. coli DHFR, delaying resistance development through efflux pump duplication.

DOI 10.7554/elife.64518

E. coliproteomics

𝕏 PostBluesky

Evolutionary BiologybioRxivAug 1, 2019

Adaptation to mutational inactivation of an essential E. coli gene converges to an accessible suboptimal fitness peak.

J. V. Rodrigues, E. Shakhnovich

The paper shows that adaptation to mutational inactivation of an essential E. coli gene converges to a suboptimal fitness peak through specific metabolic and proteomic changes.

DOI 10.7554/elife.50509

E. colimetabolomics

𝕏 PostBluesky