The lipid-mediated mechanism of mechanosensitive channel MscS inactivation
E. Moller, M. Britt, F. Zhou, H. Yang, A. Anishkin, R. K. Ernst, J. Vanegas, S. I. Sukharev, D. Matthies
This study identifies a lipid-mediated mechanism by which the mechanosensitive channel MscS inactivates, showing that intercalated lipids physically decouple tension-sensing helices from the gate.
bioRxiv · Jan 22, 2024 · PreprintBiophysics