Cell BiologyNature CommunicationsPeer-reviewed
Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling
M. G. Sugiyama, A. I. Brown, J. Vega-Lugo…·C. N. Antonescu
This study shows that EGFR confinement in tetraspanin nanodomains regulates ligand binding and signaling by preferentially facilitating ligand binding in these domains.
DOI 10.1038/s41467-023-38390-z