A. Dasgupta

Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension

This study evaluates Drpitor1a, a Drp1 inhibitor, showing efficacy in reducing PAH in female rats and human PASMCs without toxicity.

A phosphorylation-deficient ribosomal protein eS6 is largely functional in Arabidopsis thaliana, rescuing mutant defects from global translation and gene expression to photosynthesis and growth

This study shows that a phosphorylation-deficient eS6 isoform in Arabidopsis thaliana largely rescues mutant defects in growth, photosynthesis, and gene expression, with minor residual issues.

Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol for better intracellular growth

The paper shows Salmonella effector SseI recruits peroxisomes to SCVs, activates ARF-1, and facilitates cholesterol transport for bacterial growth.

Multiscale imaging and quantitative analysis of plasma membrane protein-cortical actin interplay

This paper develops a multiscale imaging framework to study the relationship between cortical actin and plasma membrane protein organization, revealing differential interactions based on protein properties and local actin environment.

RNASeq as a tool to understand dysregulation of potential biomarkers in HNSC

The paper uses RNASeq to identify differentially expressed genes in oral cancer, analyzes their functional enrichment, and identifies hub genes as potential biomarkers for margin clearance.

In vitro and in vivo activity of Gepotidacin against drug-resistant mycobacterial infections

This study evaluates Gepotidacin's activity against drug-resistant mycobacteria, showing potent in vitro and in vivo efficacy, resistance bypass, and synergistic potential.

Analysis of conditional colocalization relationships and hierarchies from three-color microscopy images

The paper introduces a method to analyze conditional colocalization in three-color microscopy images and demonstrates its application to study molecular compartmentalization and interaction hierarchies.

STED super-resolution imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes

This study demonstrates the use of NR4A, an exchangeable polarity-sensitive dye, for real-time 3D-STED imaging of membrane dynamics and biophysical properties in live cells.

Direct Supercritical Angle Localization Microscopy for Nanometer 3D Superresolution

This paper introduces SALM, a 3D superresolution technique that improves z-resolution by four times using direct splitting of supercritical and undercritical emission.

Heterogeneity in VEGF Receptor-2 mobility and organization on the endothelial cell surface leads to diverse activation models by VEGF

This study examines VEGFR-2 mobility and organization on endothelial cells, revealing how receptor heterogeneity influences VEGF activation mechanisms.

A cost-efficient open source laser engine for microscopy

The paper presents an open-source, cost-efficient laser engine for microscopy using affordable diodes and fiber delivery to reduce speckles.

Symmetry breaking during morphogenesis of a mechanosensory organ

The paper investigates symmetry breaking during zebrafish lateral line organ formation, finding two interacting symmetry-breaking events lead to collective cell migration and mirror-symmetric polarity.