Cell BiologybioRxiv
A membrane sensing mechanism couples local lipid metabolism to protein degradation at the inner nuclear membrane
S. Lee, H. Merta, J. W. C. Rodriguez, S. Bahmanyar
The paper shows that the inner nuclear membrane's lipid environment protects Sun2 from degradation by sensing diacylglycerol through an amphipathic helix, regulated by CTDNEP1 and lipin 1.
DOI 10.1083/jcb.202304026