Author

J. W. Hell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:electrophysiology· 1 Organism:mouse· 1

Frequent Co-Authors

K. N. M. Man· 2 shared M. F. Navedo· 2 shared A. M. Coleman· 1 shared A. Shen· 1 shared B. Xu· 1 shared D. Anderson· 1 shared D. Chen· 1 shared E. Kuzmenkina· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

K. N. M. Man

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2 papers

Recent·Most cited

Half-calcified Calmodulin Promotes Basal Activity and Inactivation of the Calcium Channel CaV1.2.

P. Bartels, I. C. Salveson, A. M. Coleman, D. Anderson, G. Jeng, Z. M. Estrada-Tobar, K. N. M. Man, Q. Yu, E. Kuzmenkina, M. Nieves-Cintron, M. F. Navedo, M. C. Horne, J. W. Hell, J. B. Ames

The paper identifies a half-calcified calmodulin species that promotes CaV1.2 channel activity and inactivation by interacting with specific residues in the IQ motif.

bioRxiv · Jun 24, 2022 · PreprintBiochemistry

β-blockers augment L-type Ca2+ channel activity by target-selective spatially restricted β2AR-cAMP-PKA signaling in neurons

A. Shen, D. Chen, M. Kaur, B. Xu, Q. Shi, J. Martinez, K. N. M. Man, J. W. Hell, M. F. Navedo, X. Yu, Y. Xiang

This study shows β-blockers like carvedilol can activate β2AR at low concentrations, enhancing L-type Ca2+ channel activity in neurons through localized cAMP/PKA signaling.

bioRxiv · Jun 13, 2019Cell Biology