Y. Xiang

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

This paper shows that glioma-associated fibroblasts enhance glioblastoma resistance to temozolomide by secreting CCL2, which activates the ERK1/2 pathway in cancer cells.

Metabolic phenotyping of healthy and diseased human RPE cells

This study identifies nutrient utilization differences between healthy and diseased human RPE cells, showing reduced metabolic flexibility in SFD RPE and the impact of differentiation on nutrient use.

Mitochondrial reverse electron transport in myeloid cells perpetuates neuroinflammation

The paper identifies mitochondrial reverse electron transport in myeloid cells as a driver of neuroinflammation and shows that blocking it protects the CNS in disease models.

Genomic Revisitation and Reclassification of the Genus Providencia

This study reclassifies Providencia species using genomic data, identifies a new species, and reveals high antibiotic resistance gene prevalence.

Perception of Motion Salience Shapes the Emergence of Collective Motions

The paper investigates collective motion patterns in bird flocks and develops a model based on motion salience to explain hierarchy formation and swarm behavior.

The receptor VLDLR binds East Equine Encephalitis virus through multiple distinct modes

This study identifies VLDLR as an EEEV receptor and characterizes its binding modes through cryo-EM and biochemical analyses, revealing mutations that enhance viral attachment.

Loss of Myeloid Cell-Specific β2-Adrenergic Receptor Expression Ameliorates Cardiac Function and Remodeling after Acute Ischemia

This study shows that deleting β2AR in myeloid cells improves cardiac function and reduces fibrosis after heart attack by enhancing efferocytosis of neutrophils.

Acoustomechanically activatable liposomes for ultrasonic drug uncaging

This paper introduces acoustomechanically activatable liposomes with sucrose that enable noninvasive, on-demand ultrasound-targeted drug delivery without cavitation or heating.

Laser Desorption Rapid Evaporative Ionisation Mass Spectrometry (LD-REIMS) demonstrates a direct impact of hypochlorous acid stress on PQS-mediated quorum sensing in Pseudomonas aeruginosa

This paper uses LD-REIMS to show HOCl stress reduces PQS quorum sensing and virulence factors in P. aeruginosa.

African Swine Fever Virus major capsid p72 Trimers function as a pH sensor during uncoating process of virus endocytosis

This study identifies ASFV p72 trimers as pH-sensitive structures that depolymerize in acidic endosomal conditions, explaining the pH-dependent uncoating mechanism of ASFV.

Immune-induced remodelling of mRNA structurome regulates uORF-mediated translation

The paper identifies how immune stress remodels mRNA structures to regulate uORF-mediated translation in Arabidopsis by unwinding RNA structures via RNA helicases.

Antivirals against monkeypox infections

This study evaluates 19 compounds for antiviral activity against Orthopoxviruses, identifying 13 with activity against vaccinia virus and 11 with activity against monkeypox virus.

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

This study uses metabolomics to stratify colorectal cancer tissues and identifies adenosylhomocysteinase as a potential therapeutic target.

PD-L1 regulates inflammatory macrophage development from human pluripotent stem cells by maintaining interferon-gamma signal

This study shows PD-L1 maintains IFN-gamma signaling in human pluripotent stem cell-derived macrophages, essential for their development and inflammatory function.

Ring-finger protein 34 facilitates nervous necrosis virus evading antiviral innate immunity by targeting TBK1 and IRF3 for ubiquitination and degradation

This paper identifies RNF34 as a viral E3 ubiquitin ligase that suppresses antiviral innate immunity by degrading TBK1 and IRF3, facilitating NNV replication.

Cryo-EM complex structure of active GPR75 with a nanobody

The paper reports the Cryo-EM structure of active GPR75 with a nanobody, revealing its activation mechanism and providing a structural basis for anti-obesity drug discovery.

Pore-forming protein βγ-CAT drives extracellular nutrient scavenging under cell starvation

This study identifies βγ-CAT as a pore-forming protein that enables cells to scavenge extracellular proteins under starvation by promoting nutrient uptake and survival.

Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete

This study shows that Borrelia burgdorferi is polyploid in culture and ticks, with regular genome copy spacing controlled by ParA/ParZ and ParB/SMC systems.

Gliotransmission orchestrates neuronal type-specific axon regeneration

This study shows gliotransmission via adenosine signaling determines axon regeneration in specific neuronal types, with implications for CNS repair.

Trophoblast and blood vessel organoid cultures recapitulate the role of WNT2B in promoting intravillous vascularization in human intrauterine and ectopic pregnancy

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

Conformational Flexibility in Neutralization of SARS-CoV-2 by Naturally Elicited Anti-SARS-CoV-2 Antibodies

This study evaluates the neutralizing activity of nine anti-SARS-CoV-2 monoclonal antibodies against variants of concern and reveals their structural mechanisms of action.

Hetero-bivalent Nanobodies Provide Broad-spectrum Protection against SARS-CoV-2 Variants of Concern including Omicron

This paper develops hetero-bivalent nanobodies that neutralize multiple SARS-CoV-2 variants, including Omicron, and show protective effects in vivo.

Reduced antigenicity of Omicron lowers host serologic response

The paper investigates reduced antigenicity of the Omicron variant, showing it evades antibodies and lowers serologic response, with implications for vaccine development.

Extensive in vitro and in vivo protein translation via in situ circularized RNAs

This paper introduces in situ circularized RNAs (icRNAs) that enable extensive protein translation in vitro and in vivo, with applications in immunization, genome targeting, and protein engineering.

Interaction between photoperiod and variation in circadian rhythms in tomato

The paper investigates how variation in circadian rhythms in tomato affects its response to photoperiod by analyzing transcriptomic changes in near isogenic lines with different alleles of EID1 and LNK2.

Control of Leaf Width by the APC/CTAD1-WL1-NAL1 Pathway in Rice

This study identifies the APC/CTAD1-WL1-NAL1 pathway as a regulator of leaf width in rice and shows that mutations in WL1 lead to leaf width variation.

Super-immunity by broadly protective nanobodies to sarbecoviruses

The paper isolates and characterizes ultrahigh-affinity nanobodies from a camelid immunized with SARS-CoV-2 RBD, showing broad sarbecovirus neutralization and structural insights.

Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay

This study identifies potent SARS-CoV-2 PLpro inhibitors through high-throughput screening and a FlipGFP-based assay, showing improved antiviral activity compared to existing compounds.

A concurrent canonical and modified miRNAome pan-cancer study on TCGA and TARGET cohorts leads to an enhanced resolution in cancer

The paper analyzes miRNA modifications in cancer using TCGA and TARGET datasets, showing improved clustering and prognostic insights from combining canonical and modified miRNAs.