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J. W. M. Fowler

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Cell Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

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B. Tao· 1 shared N. E. Boutagy· 1 shared R. Zhang· 1 shared W. C. Sessa· 1 shared

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2022-2022 · peak 1/yr

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B. Tao

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1 paper

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Cell BiologybioRxivPreprintMay 5, 2022

Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells

W. C. Sessa, J. W. M. Fowler, R. Zhang…·N. E. Boutagy

This study shows that inflammatory stress via NF-kB reduces accessible cholesterol, enhancing SREBP2 activity in endothelial cells, linking cholesterol homeostasis to inflammation.

DOI 10.1101/2022.05.05.490737

humanbulk RNA-seq

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