Author

J. Zevenhoven-Dobbe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1

Frequent Co-Authors

C. C. Posthuma· 2 shared E. J. Snijder· 2 shared D. Jarhad· 1 shared H. W. Lee· 1 shared L. S. Jeong· 1 shared N. S. Ogando· 1 shared N. S. S. Ogando· 1 shared S. K. Tripathi· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 23 mutual co-author links

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2 shared papersMicrobiology

C. C. Posthuma

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintMay 20, 2021

6',6'-Difluoro-aristeromycin is a potent inhibitor of MERS-coronavirus replication

N. S. S. Ogando, J. Zevenhoven-Dobbe, D. Jarhad…·C. C. Posthuma

This paper shows that 6',6'-difluoro-aristeromycin inhibits MERS-CoV replication but is cytotoxic and needs improvement for broader antiviral use.

DOI 10.1101/2021.05.20.445077

humanexperimental assay

𝕏 PostBluesky

MicrobiologyJournal of VirologyPeer-reviewedNov 9, 2020

The enzymatic activity of the nsp14 exoribonuclease is critical for replication of Middle East respiratory syndrome-coronavirus

N. S. Ogando, J. Zevenhoven-Dobbe, C. C. Posthuma, E. J. Snijder

This study shows that the ExoN activity of MERS-CoV nsp14 is essential for viral RNA synthesis, unlike in MHV and SARS-CoV where it primarily enhances replication fidelity.

DOI 10.1128/jvi.01246-20

experimental assayhost-pathogen & immune response

𝕏 PostBluesky