Author

J.-C. Barale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. B. Fisher· 1 shared A. M. Pedro· 1 shared A. Vantaux· 1 shared B. Anthony· 1 shared B. Sebastien· 1 shared B. Witkowski· 1 shared C. Botte· 1 shared C. E. Chitnis· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

A. B. Fisher

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Author profile →

3 papers

Recent·Most cited

Prodomain-driven enzyme dimerization, a potent pH-dependent autoinhibition mechanism to control Plasmodium Sub1 subtilisin-like activity prior to prime merozoite egress

J.-C. Barale, M. Mariano, B. Anthony, B. Sebastien, R. Bertrand, H. Ahmed, A. M. Pedro

This paper identifies a pH-dependent autoinhibition mechanism in Plasmodium Sub1 protease, where the prodomain drives dimerization at acidic pH to regulate enzyme activity prior to merozoite egress.

bioRxiv · Jul 31, 2023 · PreprintMicrobiology

Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target

M. P. Wagner, P. Formaglio, O. Gorgette, J. M. Dziekan, C. Huon, I. Berneburg, S. Rahlfs, J.-C. Barale, S. I. Feinstein, A. B. Fisher, D. Menard, Z. Bozdech, R. Amino, L. Touqui, C. E. Chitnis

This study shows that human PRDX6 is essential for malaria parasite survival by repairing lipid peroxidation damage and that inhibiting it can kill parasites, including artemisinin-resistant strains.

bioRxiv · Apr 11, 2022Cell Biology

Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites

K. Ashraf, S. Tajeri, C.-S. Arnold, N. Amanzougaghene, J.-F. Franetich, A. Vantaux, V. Soulard, M. Bordessoulles, G. Cazals, T. Bousema, G.-J. van Gemert, R. Le Grand, N. Dereuddre-Bosquet, J.-C. Barale, B. Witkowski, , D. Mazier

This study shows that Artemisia infusions inhibit Plasmodium stages without artemisinin, suggesting potential for new antimalarial compounds.

bioRxiv · Aug 10, 2021Microbiology