Cancer BiologybioRxivPreprint
Oncogenic RAS-MET signal interactions are modulated by P53 status in NF1-related MPNSTs
Matthew G. Pridgeon, Elizabeth A. Tovar, Curt J. Essenburg…·Matthew R. Steensma
This study shows that P53 status modulates the response to MET and MEK inhibition in NF1-related MPNSTs, with P53 wild-type tumors showing greater suppression of RAS/MAPK and PI3K/AKT activation.
DOI 10.1101/199026