Author

Jake J. Siegel

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:yeast· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:eQTL / molecular QTL mapping· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Joshua S. BloomiD· 2 shared Laura Day· 2 shared Leonid KruglyakiD· 2 shared Frank Wolfgang AlbertiD· 1 shared Meru J. SadhuiD· 1 shared Sriram KosuriiD· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 13 mutual co-author links

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2 shared papersGenetics

Joshua S. BloomORCID

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2 papers

Recent·Most cited

GeneticseLifePeer-reviewedJul 16, 2018

Genetics of trans-regulatory variation in gene expression

Frank Wolfgang Albert, Joshua S. Bloom, Jake J. Siegel…·Leonid Kruglyak

This study identifies eQTLs in yeast to show that most gene expression variation is driven by distant, trans-acting eQTLs clustered at hotspots.

197 citationstop 1%

yeastbulk RNA-seq

𝕏 PostBluesky

GenomicsNature GeneticsPeer-reviewedApr 1, 2018

Highly parallel genome variant engineering with CRISPR/Cas9 in eukaryotic cells

Meru J. Sadhu, Joshua S. Bloom, Laura Day…·Leonid Kruglyak

The paper uses CRISPR/Cas9 in yeast to engineer and screen variants, finding most premature termination codons are deleterious except near the C-terminal end.

88 citationstop 4%

yeastCRISPR screen

𝕏 PostBluesky