Frank Wolfgang Albert

The paper analyzes genetic effects on mRNA and protein abundance across multiple yeast datasets, finding high concordance with few exceptions.

The paper introduces CRI-SPA-Map, a genetic mapping strategy in yeast that identifies causal genetic variants for phenotypic differences without genotyping.

This study links the infant gut microbiome and resistome to bacterial strains in mother's milk using metagenomic samples from mother-infant pairs.

The paper investigates how genotype-by-environment interactions influence the ubiquitin-proteasome system activity in yeast by analyzing genetic effects across different environments and substrates.

The paper identifies trans-eQTL hotspots in yeast that influence growth traits by altering cellular states through widespread gene expression effects.

The paper identifies genetic loci influencing milk gene expression and links these to infant gut microbiome composition in breastfeeding mothers.

The paper investigates the association between human cytomegalovirus in breast milk and milk composition, infant gut microbiome, and infant growth.

The paper identifies 15 genomic loci influencing proteasome activity in yeast using single-cell measurements and CRISPR-based engineering, revealing substrate-specific genetic effects.

The paper identifies genetic variants affecting UPS activity in yeast by mapping loci influencing N-degron recognition and ubiquitination.

The paper identifies multiple causal DNA variants within a single gene that affect gene expression in trans in yeast, showing complexity in trans-acting variation.

The paper shows trans-eQTLs in yeast can affect adjacent genes through horizontal mechanisms, not just vertical pathways, and this is linked to physical proximity and shared chromatin states.

A CRISPR-based dual reporter assay identifies DNA variants affecting mRNA or protein levels in trans in yeast.

The paper identifies 451 causal regulatory variants in yeast promoters using a massively parallel reporter assay and finds they show epistasis, conservation, and enrichment in transcription factor binding sites.

The paper identifies three trans-acting variants in yeast that affect gene expression through diverse mechanisms and evolutionary patterns.

This study identifies eQTLs in yeast to show that most gene expression variation is driven by distant, trans-acting eQTLs clustered at hotspots.