Author

Jake Newton

Centre for Life

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Developmental Biology· 1

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Approach:experimental assay· 1 Organism:mouse· 1

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Ahlam AlqahtaniiD· 1 shared Bill ChaudhryiD· 1 shared Chloe Connolly· 1 shared Christopher J. DerrickiD· 1 shared Cindy Rodrigues-Cleto· 1 shared Deborah J. HendersoniD· 1 shared Hana KolesováiD· 1 shared Javier Arias· 1 shared

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1 shared paperDevelopmental Biology

Ahlam AlqahtaniORCID

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1 paper

Recent·Most cited

Developmental BiologyCardiovascular ResearchPeer-reviewedJun 10, 2025

Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve (BAV) caused by loss of primary cilia

Ahlam Alqahtani, Lorraine Eley, Jake Newton…·Deborah J. Henderson

This study shows that loss of primary cilia in second heart field cells causes bicuspid aortic valve by disrupting Notch-Jag1 signaling and altering valve leaflet formation.

3 citations

mouseexperimental assay

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