Author
University of Massachusetts Chan Medical School
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Michael W. Lero, Jennifer S. Morgan, Michael-Anthony Card…·Leslie M. J. Shaw
This study identifies IRS2 as a mediator of resistance to PI3K pathway inhibitors in PIK3CA mutant breast cancer by sustaining PI3K signaling through FOXO3-mediated regulation.
Ji-Sun Lee, Quyen Thu Bui, Minjeong Jo…·Leslie M. Shaw
This study identifies IRS2's role in protecting cells from mitotic stress through its interaction with PLK1, distinct from its signaling function.
Claire E. Tocheny, Julianna E. Buchwald, Christopher D Dahlke…·Leslie M. Shaw
This study delivers IRS2-targeting siRNAs to mammary tumors via albumin-binding dendrimers, reducing tumor growth by inhibiting Irs2 expression and altering tumor microenvironment features.
Minjeong Jo, Jisun Lee, Claire E. Tocheny…·Leslie M. Shaw
This study uses CRISPR/Cas9 to fluorescently tag endogenous IRS2 with an auxin-dependent degron, revealing its dynamic nuclear-cytoplasmic shuttling and role in cancer stem cell function.