Author

Quyen Thu Bui

University of Massachusetts Chan Medical SchoolORCID 0000-0002-3195-9404Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jennifer S. Morgan· 3 shared Leslie M. ShawiD· 2 shared Michael W. LeroiD· 2 shared Minjeong JoiD· 2 shared Arminja Nadine KettenbachiD· 1 shared Claire E. TochenyiD· 1 shared Emma MohlmanniD· 1 shared Hira Lal Goel· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

Jennifer S. Morgan

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3 papers

Recent·Most cited

Cancer BiologyJournal of Biological ChemistryPeer-reviewedAug 10, 2026

Insulin receptor substrate 2 (IRS2) confers resistance to PI3K pathway inhibition in PIK3CA mutant breast cancer

Michael W. Lero, Jennifer S. Morgan, Michael-Anthony Card…·Leslie M. J. Shaw

This study identifies IRS2 as a mediator of resistance to PI3K pathway inhibitors in PIK3CA mutant breast cancer by sustaining PI3K signaling through FOXO3-mediated regulation.

DOI 10.1016/j.jbc.2026.113426

humanbulk RNA-seq

𝕏 PostBluesky

Cell BiologyCell Death and DiseasePeer-reviewedApr 8, 2026

Interaction of IRS2 with PLK1 protects cells from mitotic stress

Ji-Sun Lee, Quyen Thu Bui, Minjeong Jo…·Leslie M. Shaw

This study identifies IRS2's role in protecting cells from mitotic stress through its interaction with PLK1, distinct from its signaling function.

1 citation

humanproteomics

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Cell BiologyJournal of Biological ChemistryPeer-reviewedSep 19, 2024

Fluorescent tagging of endogenous IRS2 with an auxin-dependent degron to assess dynamic intracellular localization and function

Minjeong Jo, Jisun Lee, Claire E. Tocheny…·Leslie M. Shaw

This study uses CRISPR/Cas9 to fluorescently tag endogenous IRS2 with an auxin-dependent degron, revealing its dynamic nuclear-cytoplasmic shuttling and role in cancer stem cell function.

3 citations

humanfluorescence / live-cell microscopy

𝕏 PostBluesky