Synthetic BiologybioRxivPreprint
A High-Efficiency Geranylation Platform Enabled by Rational Tuning of a Single-Residue-Coded Chemo- and Regioselective Switch in Aromatic Prenyltransferases
Ruiying Qiu, Hong Zhang, Min Li…·Jian-bo Wang
This paper identifies a single-residue switch in prenyltransferases that enables both broad substrate scope and high selectivity for geranylation, achieving 41 products from 36 substrates.
DOI 10.64898/2026.11.09.764520