Molecular BiologybioRxivPreprint
A circRNA-based uricase replacement therapy for sustained treatment of hyperuricemia
Zheyu Zhang, Jiewen Zhong, Kai Zhang…·Zefeng Wang
This study develops a circRNA-based uricase replacement therapy that reduces serum urate levels and maintains efficacy for up to 10 weeks in uricase-knockout mice.
DOI 10.64898/2026.03.19.712815