Molecular plasticity in the flavin binding pocket of BLUF domain evolves first light-gated endonuclease in bacterial system
Rahamtullah, Jitender, Manish Singh Kaushik, Sagar Kumar, А. Penzkofer, Andreas Möglich, Suneel Kateriya
The paper studies how evolutionary changes in the BLUF domain of Rubellimicrobium mesophilum affect photodynamics and endonuclease activity, revealing a light-gated endonuclease mechanism.
bioRxiv · May 5, 2025 · PreprintBiochemistry