GenomicsGenome biologyPeer-reviewed
The fitness cost of mis-splicing is the main determinant of alternative splicing patterns
Baptiste Saudemont, Alexandra Popa, Joanna L. Parmley…·Laurent Duret
The paper quantifies the fraction of alternative splicing events that are errors by analyzing transcriptomes of Paramecium tetraurelia and humans, finding that 92%-98% of splice variants in medium-expressed genes are errors.