Baptiste Saudemont

This paper characterizes OLD, an abortive immunity protein, revealing its structure and activation mechanism in response to phage replication and DNA defects in RecBCD-compromised cells.

The paper identifies additional tRNA targets of the AriB nuclease in the PARIS system and shows that phage-encoded tRNAs can inhibit this defense.

The paper shows that viral proteins activate PARIS-mediated tRNA degradation, and viral tRNAs rescue infection by preventing cleavage.

This study uses TATTOO-seq to identify spatial and cell type-specific regulatory programs during limb development and shows how perturbations affect cell fate and spatial organization.

The paper quantifies the fraction of alternative splicing events that are errors by analyzing transcriptomes of Paramecium tetraurelia and humans, finding that 92%-98% of splice variants in medium-expressed genes are errors.