Cancer BiologyCell GenomicsPeer-reviewed
Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification
Jeremiah A. Wala, Simona Dalin, Sophie Webster…·Verónica Rendo
This study shows that BRD4 gene deletions reduce toxicity from overexpression in ovarian and breast cancers, providing evidence for a novel mechanism in cancer progression.
DOI 10.1016/j.xgen.2025.100815