Verónica Rendo

This study shows BMP4 induces p21-dependent senescence in glioblastoma cells, especially in therapy-resistant mesenchymal-like clones, linking mesenchymal transition to senescence.

This study shows that BRD4 gene deletions reduce toxicity from overexpression in ovarian and breast cancers, providing evidence for a novel mechanism in cancer progression.

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

The paper compares three scRNA-seq methods for ex vivo drug screening in ALL cells, finding consistent transcriptional responses to fludarabine despite method-specific differences.