Author

John W. McLean

University of Arizona

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 1

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Assay:metabolomics· 1 Organism:mouse· 1 Approach:statistical model· 1

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Fei YiniD· 1 shared Roberta Dı́az BrintoniD· 1 shared Tian WangiD· 1 shared Yuan Shang· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperNeuroscience

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1 paper

Recent·Most cited

NeuroscienceFrontiers in Aging NeurosciencePeer-reviewedJun 2, 2026

APOE4 Accelerates Menopause-Associated Brain Metabolic Shift and Disrupts Bioenergetic Adaptation

Tian Wang, Yuan Shang, John W. McLean…·Roberta Dı́az Brinton

This study shows that APOE4 accelerates menopause-related metabolic decline and impairs bioenergetic adaptation in the brain, increasing Alzheimer's disease risk.

1 citation

mousemetabolomics

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