Animal Behavior & CognitionbioRxivPreprint
Voluntary oxycodone self-administration produces analgesic tolerance and sex-dependent hyperalgesia across genetically diverse rats
Tolulope J. Ajanaku, Eamonn P. Duffy, Jonathon O. Ward…·Ryan K. Bachtell
This study shows that voluntary oxycodone self-administration in rats leads to analgesic tolerance and sex-dependent hyperalgesia, with genetic strain differences in thermal sensitivity and analgesic response.
DOI 10.64898/2026.08.20.745912