Zhiyu Zhao

This study shows that glutathione is essential for proteostasis in hematopoietic stem cells but not for ferroptosis prevention.

The paper identifies LepR+ cells as a niche for thrombopoiesis by producing CXCL14, which regulates lipid metabolism and terminal differentiation in megakaryocytes.

This study shows that SCF produced locally in bone marrow stromal and endothelial cells supports hematopoietic stem and progenitor cell maintenance, while systemic SCF does not.

This study shows that TCA cycle turning is not essential for stem and progenitor cell survival or proliferation and its loss enhances stem cell function in hematopoiesis.

This study shows that ACC1-dependent de novo fatty acid synthesis is essential for maintaining HSC quiescence and self-renewal, with its loss leading to impaired function and increased fatty acid oxidation.

Sustained interferon exposure in inflamed tumor regions enhances metastatic potential of melanoma cells via increased CD47 expression, protecting them from macrophage phagocytosis.

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

This study shows autophagy compensates for inflammation-induced metabolic issues in old HSCs, and temporarily boosting autophagy can restore their function.

This study identifies integrin alpha11 as the receptor for Osteolectin, showing its role in osteogenic differentiation and bone mass maintenance through Wnt pathway activation.