Cancer BiologybioRxivPreprint
Complex I Drives Glutamine-Dependent TCA Cycle to Support Viability of MYChigh Breast Cancer Cells
Johanna M. Anttila, Mariel Savelius, Juhi Somani…·Juha T. Klefström
This study identifies enhanced mitochondrial respiration and glutamine-dependent TCA cycle as vulnerabilities in MYChigh breast cancer cells, showing synthetic lethality with complex I inhibitors.
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