ImmunologybioRxivPreprint
Reverse engineering the fatally cross-reactive A3A TCR to decouple potency and specificity
Julia V McCarthy, A. Christina Heroven, King Ifashe…·Ricardo A. Fernandes
The paper reverse-engineers a TCR to reduce cross-reactivity while maintaining potency by reverting specific residues.
DOI 10.64898/2026.05.03.722528