Ricardo A. Fernandes

This study shows that low CAR affinity improves T-cell synapse dynamics and activation by promoting receptor turnover and signaling.

This study shows that CXCR3 on transferred T cells enhances the effectiveness of combining adoptive T-cell therapy with viral-vector vaccines in solid tumors.

The paper reverse-engineers a TCR to reduce cross-reactivity while maintaining potency by reverting specific residues.

This paper introduces BAFS, a method to measure receptor-antigen binding strength in immune synapses with high precision and reduced non-specific binding.

This paper introduces patch deconvolution to accelerate 3D cellular imaging in Fourier light-field microscopy, achieving faster reconstruction speeds without compromising quality.

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

This paper introduces TRAP, a deep learning platform for predicting CD8+ T-cell epitopes, which outperforms existing methods in cancer and pathogenic settings.