Synthetic BiologyThe CRISPR JournalPeer-reviewed
Increasing the effective gene drive homing rate by targeting the haploinsufficient spermatogenesis gene KLHL10
Ceili L. Peng, W. Sebastian Kamau, Julien Freeman…·Kevin M. Esvelt
This paper demonstrates a gene drive strategy targeting KLHL10 in mice to increase homing efficiency by removing NHEJ-mutated sperm, but observes unexpected mutation absence in female offspring.
DOI 10.1177/25731599261452112