Leiqing Zhang

This study shows that combining ONC201 with ATR inhibitor ceralasertib synergistically kills ovarian cancer cells by inducing apoptosis and reducing anti-apoptotic proteins.

This paper shows that combining ONC201 or ONC206 with temozolomide and radiotherapy significantly extends survival in a GBM mouse model compared to single treatments.

This study identifies nSMase2 as a critical mediator of Doxorubicin-induced cardiotoxicity and shows its loss protects against cardiac damage.

This study shows that combining ONC201 with enzalutamide or darolutamide synergistically reduces mCRPC cell viability and PSA levels, with in vivo anti-tumor effects.

This study shows that MRTX1133, a KRAS G12D inhibitor, synergizes with 5-FU or ONC212 to reduce tumor cell viability and pERK in CRC and pancreatic cancer cells, regardless of KRAS mutation status.

This study shows that androgen receptor inhibitors enhance NK cell-mediated killing of prostate cancer cells and sensitivity to NKG2A checkpoint blockade by upregulating HLA-E expression.

This study shows that combining lurbinectedin with irinotecan and 5-FU significantly enhances the killing of pancreatic cancer cells.