K S Kosik

This study demonstrates goal-directed learning in cortical organoids using a closed-loop electrophysiology framework and artificial reinforcement learning.

This study shows that PGRN loss in human cerebral organoids causes mitochondrial dysfunction and ferroptosis through oxidative stress and iron accumulation.

The paper designs synthetic tau fibrils that mimic AD and CTE structures, showing strong seeding ability and catalytic effects in vitro and in cells.

This study identifies how APOE3-Christchurch astrocytes protect against Alzheimer's by enhancing tau clearance and reducing harmful lipids.