BiochemistrybioRxiv
Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol
K. A. Manthei, S.-M. Yang, B. Baljinnyam…·J. J. G. Tesmer
The paper reports the crystal structure of LCAT bound to an activator and inhibitor, showing how the activator stabilizes the MBD and enhances LCAT activity in FLD variants.
DOI 10.7554/elife.41604